The Best Sci-Fi Movies With Female Leads

Jason Bancroft
Updated March 5, 2026 58 items
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344voters2.9Kvotes

The best female-led science fiction movies are a major reason why the world is paying attention to films with female leads more than ever. It's always a great time of year to show respect and admiration to the impressively talented women who have been cast in starring roles across all genres – but for this list, we are going to focus on science fiction. The Alien franchise boasts mutiple leading ladies as well as the Resident Evil franchise which is helmed by the talented Milla Jovovich. There are plenty of other science fiction films with women in lead roles that are worth mentioning and you'll find them on the list below.

There are countless sci-fi movies with female leads to binge-watch on streaming platforms like Netflix, Hulu, HBO Max, and Disney+. There are also tons of epic sci-fi movies getting released in theaters every year! These are some of the most noteworthy sci-fi flicks with empowering female actresses taking the lead. 

Latest additions: The Bride, In the Blink of an Eye, Redux Redux
Over 300 Ranker voters have come together to rank this list of The Best Sci-Fi Movies With Female Leads
This list is dynamically ranked based on user voting. The order reflects the consensus of our voters and is not influenced by paid placements or editorial bias.
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